Endocrine Abstracts

Objective: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) it’s a histological entity that describes a low-aggressive neoplasm previously classified as encapsulated follicular variant of papillary thyroid carcinoma and well differentiated tumour of uncertain malignant potential. The preoperative diagnosis it’s difficult, and if we suspect it hemithyroidectomy or lobectomy it’s the therapeutic management of choice. Therefore,...

Introduction: Sclerostin, produced by osteocytes, is a potent inhibitor of Wnt signaling and bone formation. The usefulness of its determination in clinical practice is not well established.Objectives: The aims of this study were to evaluate serum sclerostin levels in a cohort of Spanish posmenopausal women, and to analyze its relationship with bone metabolism.Methods: We measured serum sclerostin in 97 posmenopausal women using EL...

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism if patients do not accept surgery, do not carry out the surgical criteria, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that included 20 patients with primary hyperparathyroidism who had complete at least 12 months of treatment with cinacalcet for different reasons (eight patients r...

Introduction: Diabetes mellitus is associated with an increased risk of osteoporotic fractures, which leads to an increased risk of disability and frailty.Aims: To assess the prevalence of frailty in type 2 diabetes and to analyze the relationship with bone mineral density (BMD) and Trabecular Bone Score (TBS), fracture risk and prevalent fractures.Methods: We carried out a cross-sectional study of 75 diabetic patients (65±7 y...

Introduction: Cardiovascular disease (CVD) is a health issue, worldwide, particularly in individuals with diabetes. The identification of CVD biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and has recently been linked to vascular biology.Objectives: Our objective was to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardio...

Introduction: Sclerostin is a glycoprotein expressed mainly by osteocytes, which acts as inhibitor of bone formation. However, several studies have shown an increase in serum levels of sclerostin in subjects with type 2 diabetes (T2D) and cardiovascular disease (CVD) suggesting an additional role of this protein at the vascular level. The hypothesis that sclerostin could be expressed by vascular smooth muscle cells (VSMCs) under calcifying conditions could justify this elevati...